Jake Orville serves as general manager of Screening. He previously served as general manager, Pipeline since February 2019. Prior to joining Exact Sciences in 2019, Orville served as general manager, Cardiometabolic & Endocrinology Franchise at Quest Diagnostics, Inc. In 2008, Orville co-founded Cleveland HeartLab, Inc., and served as its chief executive officer through 2017 when Cleveland HeartLab was acquired by Quest Diagnostics. Earlier in his career, Orville served in leadership and operational roles at NextGen Sciences, Inc., and Third Wave Technologies, Inc. Orville holds a bachelor's degree from the University of Massachusetts-Amherst and a Master of Business Administration from the University of Wisconsin-Madison. Orville currently serves as a board member of the Wisconsin Women’s Health Foundation.